She was best known for her comic portrayal of Witchiepoo on NBC's Sid and Marty Krofft television series H.R. Pufnstuf. Her characteristic cackle and animated physicality were notable during the show's 17-episode run in 1969–70. She reprised this role in The Paul Lynde Halloween Special. Hayes portrayed a similar character in other roles, including Episode 8.10 of Bewitched ("Hansel and Gretel in Samantha-Land"), Weenie the Genie in the Sid and Marty Krofft program Lidsville, and Maw Weskitt in Episode 39 of the second season of The Monkees ("Hillbilly Honeymoon").
Hayes played Mammy Yokum in both the Broadway and film versions of Li'l Abner, appeared on the soap opera General Hospital as Robert Scorpio's mentor, "O'Reilly" in 1981 and 1985, and did the voiceover for the character Mother Mae-Eye on the animated series Teen Titans and the character Granny Applecheeks in The Grim Adventures of Billy & Mandy. Hayes also had a short role in The Wacky Adventures of Ronald McDonald as One-Eyed Sally.
Also, she was the voice of the old lady from the original Powerpuff Girls episode "Bang For Your Buck". Her first voice role was as a character named Orgoch on the Disney feature film The Black Cauldron in 1985. Other voice work has included roles on cartoons such as The Further Adventures of SuperTed, Johnny Bravo, W.I.T.C.H., The Batman, Tale Spin, and Darkwing Duck. Hayes is the president of the animal rescue organization Pet Hope, which she founded in 1984 to care for and find homes for abandoned animals. On her personal website, Hayes offers autographed photos for donations to Pet Hope as charity.
|Teen Titans Go! Cast|
|Creators||Michael Jelenic • Aaron Horvath • Peter Rida Michail • Luke Cormican • Scott O'Brien • Jeff Mednikow • James Krenzke • Glen Murakami • Peggy Regan • Sam Register|
|Main Cast||Scott Menville • Hynden Walch • Tara Strong • Greg Cipes • Khary Payton|
|Supporting Cast/Guest Cast||Lauren Tom • John DiMaggio • Rodger Bumpass • Ashley Johnson • Kevin Michael Richardson • Billie Hayes • Tom Kenny • Freddy Rodriguez • Wil Wheaton • Kate Micucci • Nika Futterman • Jeff Bennett • Eric Bauza • Roz Ryan • David Kaye • Alexander Polinsky • Will Friedle • Dee Bradley Baker • Dwight Schultz • Pamela Adlon • "Weird Al" Yankovic • LeBron James • Fall Out Boy • CeeLo Green • Cree Summer • Will Arnett • Kristen Bell • James Corden • Nicolas Cage • Halsey • Lil Yachty • Jimmy Kimmel|